IMO Super Vision is the only absolutely necessary piece, but that is only because I don't like to pay full price for high SA's.
High vision (90+ after bonuses) with 10 SV produces plays like these:
http://goallineblitz.com/game/replay.pl?game_id=1639356&pbp_id=6287346http://goallineblitz.com/game/replay.pl?game_id=1569508&pbp_id=9235014The FS starts breaking on the ball (and getting his Ball Hawk bonus) the same tick the quarterback starts to cock his arm back. This one was a pick, but that kind of reaction time is just as useful in the run game.
I am also a big fan of Avoid Fake %, since it helps in both the pass and run game as well. Beyond that it depends on your build and what you are trying to focus on.