Originally posted by pottsman
No matter what, if you replace the player, you're going to take a chemistry hit.
10 days of inactivity works out to about 4500 skill points unspent, being unused by your inactive player. If you can find a player, even unboosted, they are caught up to your inactive and better.
Pretty much, unless you know the person is coming back, cut the player and move on after the ten day point. I just cut a friend's player, he hit 14 days inactive this morning, the missing skill points amount for a lot more than the chemistry hit.
I wait exactly seven days, unless the player posted before he went saying "I'm going on vacation, etc.."