I would love to have this. If an API was available, that I could pass in a replay ID, and could get the game information in XML format, it would make life very easy. The information Thunderoo pulls from his current script would be great starting place. The extra pieces that I would like to see included, that he can't find on the page right now, is Field position on each play, as well as the offensive and defensive formations (currently, he calculates the def formation from players positions)
I am thinking very basic and standard xml, with no need for a defined schema(xsd) to check against, etc
<Game>17543</Game>
<GameOpponents>
<HomeTeam>Team 1</HomeTeam>
<VisitingTeam>Team 2</VisitingTeam>
</GameOpponents>
<PlayByPlay>
<Play 1>
<Parameters>
<Quarter>1</Quarter>
<Time>14:51</Time>
<FieldPosition>Offense</FieldPosition>
<FieldYardLine>20</FieldYardLine>
<Down>1</Down>
<Distance>10</Distance>
</Parameters>
<Offense>
<TeamName>Team 1</TeamName>
<Formation>Strong I Formation</Formation>
<Play>HB Counter Weak</Play>
<WRCount>2</WRCount>
</Offense>
<Defense>
<TeamName>Team 2</TeamName>
<Formation>4-3</Formation>
<Play>Cover 2 Man Under</Play>
</Defense>
<Result>
<Yardage>3</Yardage>
<Turnover>0</Turnover>
<Description>QB Ball Handler handed off to HB The Original for a 3 yard gain.</Description>
<Link>
http://glb2.warriorgeneral.com/game/replay/14279/152786</Link> </Result>
</Play>
</PlayByPlay>
</Game>
This would be for scouting, I could see other API's, like getting a teams schedule(league/ladder, etc, not sure that scrimmages would be worth it) and that would include the replay link, possibly matchup link, etc.
A little more difficult API(security reasons) would be to pull your players personal information (attributes, etc) so you could watch the growth in different ways, and compare certain attribute growths to game performances. Again, this one may be too hard, for very very little gain. I would admit im a regular stat geek

ETA: my formatting didn't keep with XML, so its not as easy to read. you could paste it into an xml editor and it should autoformat correctly.