There's plenty of ways to make that work. You'd have to stack the planet, but after that, there's plenty of tools that are in place now - whether they'll still be there is not yet known.
Remember that out cuts on here don't exist, so you could refuse in cuts all day long. The route combo's don't do anything to stretch a zone vertically, which is how a zone is busted, so you don't have to worry about that.
You could naturally take away;
WR digs
TE pipes
and any double move.
After that, what routes are run? The only thing they could get every down are anything behind the L.O.S. to backs.
Let's try a scenario - strong-I, 2nd and long, elusive back on the field. Get the imbalance of the defensive line over the strong side of the offense, stack all 3 backers and introduce the SS in a 9 technique. Have him cover the numbers near the flanker, or same side receiver. Cover zone immediately. SS gets primary force vs. the pitch and forces the flanker to lengthen his stem vs. a 3 deep zone. The split-end, WR1, sees ROLB, CB1 and Free Safety. He's out. TE sees MLB, LOLB and FS. He's out. That's pretty tough to deal with. All the while the QB's holdin' the ball and routes have to develop and your pressure can get there. You can even use a bunch of fire zones too - get a numbers advantage to one side and get bodies deeper in the backfield before they see a blocker.
On here, it's definitely something you could do, but the WR build culture replicates Randy Moss, so with everything being downfield, it's mano-a-mano in jump ball situations if the QB pulls the trigger. That could cause a problem. Move to quarters, and you have a bigger problem with too much field available short. Move to 4 and 4, and you have no pass rush.
It'll be the same as man to man - can your corners hold up? You'll have to start with a 3 deep zone. Play 2 deep/5 under zone, a double zone or the classic cover 2, then you've committed too many closer to the L.O.S. and you'll have defenders covering air all down long.
