I'd like to see a legit true 4 WR formation at some point (think Run-and-Shoot with QB under center or the current "spread" style ala Mike Leach at Texas Tech).
In terms of plays, it'd be nice to see more variations in the plays (especially passing) themselves.
Example: Long TE there's only 4 passes. 2 are the same play virtually, just in different formations. There's no Square Out, no Square In, no Deep Post Inside or Deep Post outside (aside from a fake in to out).
Long HB has just 2 plays! Both are basically verticals. There's no pass that is an arrow to the sidelines for example or even a wheel route down the sideline.
I understand the sentiment from defensive coordinators that an OPC would be prone to exploits but it'd also give the user base a HUGE ability to actually create their own offensive playbooks the way they want. If a guy wants to create a Mike Leach style Air Raid playbook they can or they can create their own West Coast Offense look.
I'll see if I can edit this post later with some quickly drawn up plays using GLB formations. Not sure how to get the blank GLB play thing that others use though.
Edited to add what I created very quickly using just I Formation and 5 WR formations.
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http://yfrog.com/jx5widesquareoutsj 5 WR Square Outs
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http://yfrog.com/jq5widepostsj 5 WR Inside Posts
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http://yfrog.com/j45wideinoutpostsj 5 WR Inside and Outside Posts
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http://yfrog.com/eu5widelevelsj 5 WR Levels 1
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http://yfrog.com/iy5widelevels2j 5 WR Levels 2
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http://yfrog.com/j35wideinsideswitchroutej 5 WR Inside Switch Route
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http://yfrog.com/b85wideinsidebuttonsj 5 WR Inside Button Hooks
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http://yfrog.com/27iformationtesquareoutj I Formation TE Square Out
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http://yfrog.com/abiformationtesquareinj I Formation TE Square In
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http://yfrog.com/1fiformationteinsidepostj IFormation TE Inside Post
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http://yfrog.com/euiformationtebuttonhookj I Formation TE Outside Button Hook
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http://yfrog.com/3miformationhbwheelj I Formation HB Wheel Route
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http://yfrog.com/4xiformationfbwheelj I Formation FB Wheel Route