Points/league structure make a lot of difference. I don't understand the whole theory behind having QBs score a 100-freaking-points in a single game, but whatever makes you happy. I, personally, have my league in default scoring for both PPR and non-PPR leagues, set for 10-man in each of them.
To summarize...
8-man league, 10-man league, if you pick up a QB in the first round you're a dipshit like sf49r09 over there.
Who would you rather have?
Joseph Addai and Tony Romo?
Or Tom Brady and Michael Turner?
Now in a 12-man or more league, that's a little different. All the good QBs may be gone by the team it comes back around to you (Brady, Manning, Manning, Romo, Palmer, Brees, Anderson, Roethlisberger etc.) so you may be inclined to pick up a QB that early.
Or hold out hopes you can snag a Garrard, or a Favre, or a Garcia, or a Leinart/Warner later on in the draft.
I'm all for drafting a QB early, as long it provides me with the best value for that pick. Value-based drafting is where it's at. A lot of people look down on it, thinking RB-RB is the best formula, but if you know your spots, the ADP of the players, and spots where you could grab an equal or slightly lesser player later in the draft in order to pick a stronger player now (in this case, sacrifice a Brady in the first for a Palmer or Brees in the third, while picking up an Addai/MB3 for one and two) you could still end up with a very stacked roster.
Of course, if Brady/Manning is still there in the second round (doubt it) then you may want to grab him, if that's what you want.
Even yet, I wouldn't take either of them. Best value will most likely be a RB, maybe even a WR.
But if you want to be like Evergay, then take Brady with the fifth or Manning with the seventh (in a normal, non-retarded league).
And I'm sure your $200 buy-in will be appreciated by everyone else in your league.