Originally posted by Xars
The best offenses are simple offenses were every roster slot and every dollar of salary cap provides maximum value on every play.Congratulations Xars, you've won the game

In a nutshell, just because there are all these different formations does not mean you should use all these different formations. Nor should you construct your roster in a way to provide the flexibility to use all the different formations.
It's much better to focus on doing a small handful of things really, really well. This lets you get away with a smaller roster, and thus more superstars, which further enhances your ability to really hammer away at a specific strategy.
The same thing applies on defense. Just because there's a whole bunch of formations you can use, doesn't mean you should. It's way better to build your roster to do something really well, and trust your builds, than to have defenders doing stuff they're not built to do. Nor is it a good idea to try and build your defender to do everything. They'll just suck at everything. Figure out the skills you can ignore based on some specific type of scheme by your defensive coordinator, and go build to do that, and coordinate to do that, and your team will be much better for it.