I'd rather have 2 S* DE's built like this...
http://www.glb2scout.com/vpimages/239_NEW_1459388456.pngThen 3 normal DE's and 1 S* DE.
the 2 S* De's are cheaper than the 4 DE setup anyways.
Against S* OT's, or pure pass/pure rush teams the DE's will be taken out of the play more often and their numbers will drop, but they still have high value in the game. Even if I couldn't do S* De's, I'd rather just have two combo DE's built like this.
http://www.glb2scout.com/vpimages/239_NEW_1459388938.pngOr 3 Normal DE's with one combo, one run stuffer, and one pass rusher, and then simply using custom depth charts to set up a proper snap count depending on the offense that is faced. I guess it'd depend on the Rest of the roster, but I'd never have more than 3 DE's, they are simply too expensive to justify 4 DE's. And considering what can be done with the, you could even get away with 1 S* DE, and 1 combo DE if conditioning is managed right. Hell even 2 non S* Combo DE's could still be good. Honestly, I think I'm more inclined to 2 DE's than I am to 3 or 4.
One of the biggest problems with team building is agents undervaluing certain skills in their builds, if you get 3-4 DE's but no one has conditioning past 45 or so at end build, then you NEED that heavy of a rotation to maintain energy, but you could have guys on the field for 100% of the snaps if conditioning is 70-75, and what that allows you to do with the rest of your roster is worth it in my opinion if you can get the agents together for the S*'s.
Freeing up salary for S* LB's, S* Cb's, and a S* SS is more important because I think they can offer more to a team than a S* DE. I mean S* De's are great and all, but a S* LB, or S* SS is greater.