Couple things, just glancing at your roster and depth chart.
a) Run plays have a strong tendancy to go to the right. So, to counter that, the left side of your defense needs to be shored up, IE your LDE and your LOLB. I would move your MLB to the LOLB. Generally speaking, the LOLB has to be the best LB on your team, particularly when you aren't strong across the board in player levels.
b) Take the above, and apply that to your offensive line. If run plays have a tendancy to go right, even out your line a bit more to the right side. The ROT is arguably the most important person on that line.
Couple things in general:
-Read every guide posted about skill builds and daily training. Then, create a development plan for your team, based on how you want to play football in GLB. Last year, as Fiddy said above, we were a brand new team in arguably the toughest conference in the game. So, instead of lamenting and crying about our 100 pts losses, we started thinking bout this season. Discussions came up about how we wanted to play on offense, on defense, pieces we would need, etc. In the end, we decided on gameplans for both sides of the football, and built our players around those premises. As he also said, we made depth a priority, leveling out playing time as much as we could. We weren't just building starters, but backups that could slide into starter spots, as well.
-Read the forums from other leagues. Want the best way to find out tips and tricks, read up. People will post things, sometimes without realizing about it.
-Be prepared to put ample amount of time into this game. Just like IRL, football can be a complicated game that requires time to break down to the baseline x's and o's.
-SCOUT SCOUT SCOUT your opponents. I'm the D coordinator for the Lowell Tigers, and I can honestly tell you I have done the following (as soon as we knew what league we were in and what our schedule was):
-Reviewed each team pre-season, taking notes on levels, last years success/failures.
-Reviewed gamefilm from last year, of our opponents. I probabley watched about 40 games in total.
-Created specific threads in our forums about each team. Strengths/weaknesses, player personel, our gameplan against them, and a post mortem section to dissect what went well and what didn't work are typical things in each post.
And now, with the season started, i've watched games for each team we play, i've gone back over DC's, etc.
It's amazing the knowledge you gain from simply looking at DC's (depth charts).
Anyhow, these are just some things you can do.