It's not the Speed that is the liability, it's the strength and weight
Run blocking right OTs usually weigh 350 pounds and stack all EQ into Strength getting north of 150 total. You can't send a 240 pound weenie DE against that at all. That relegates him to being a RDE to face the Left OTs.
LOTs are almost always 300+ Pounds, and they usually have Strength north of 130 total... usually 90+ Strength at least, and most, if not all EQ in Strength.
When pass rushing, DEs can get around them with huge amounts of Speed.
The problem comes in the run defense department. When you're a DE that's built like a line backer (von miller is listed at 250 pounds for example) the defensive coordinator has no options.
https://postimg.cc/bDG8HvvcThe custom depth charts do not allow for different DEs to be subbed in. That's why if you want to do a speed DE type of build, he should be built as a linebacker, or even better, as a CB that can be brought in in specific situations. The DE has no flexibility. There's a left and right DE on the D-line on every defensive play. There's no good way to control when DEs go into the game. The coordinators can try to fudge it with energy/stamina substitution settings, and by trying to force starters, but that becomes a mess that can be exploited by the opposing team.
Do yourself, and your future team a favor... Build a DE built to stop the run first and foremost. OR Build a pass rusher out of another position.
That being said, if you build the DE you're talking about, 110/80/100 would be an awesome build-- stack all your EQ into Strength and you'll be a killer. You won't be Dwight Freeney 6-1 270lbs, but you'll be a huge asset to your team.
If you want Dwight Freeney 6-1 270lbs, look at the Blitzer LB archetype
Blitzer
A blitzer linebacker loves to rush the quarterback. He is fast and a good tackler, though he is not exceptionally strong. He is great coming off of the edge, and can rack up plenty of sacks and hurries. He may find himself in trouble when facing strong blockers, however, if he cannot find his way around them.5'10" - 6'6", 240-270 LbsMajor Attributes: Agility, Jumping, Speed, Tackling (+.5)
Minor Attributes: Confidence, Stamina, Strength, Vision (+.25)
Favored Special Abilities: Shed Block, Big Sack
Penalized Special Abilities: Aura of Intimidation, Diving Tackle
LBs can have jersey numbers in the 90s
If you could settle on a 6-0 LB, you could hit agility first. You'd have the 270 weight, but you'd have to hit Speed 2nd.
if you could manage 105 Speed, 100 Agility, and 85+ Strength that would be a great build. The difference would be, if you want maximum pass rush potential, you'd have to go all EQ into Speed.
** full disclosure here: I'm a defensive coordinator, and I'm building 2 identical pure power DEs